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Hangover remedy protects and prevents cirrhosis
Posted date 08/05/2019
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Posted date 08/05/2019
2.186 view
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The hangover tree is an imported plant, currently growing in Cao Bang and Lang Son. The medicinal herb “Chi cu tu” is the fruit and the fruit-bearing branches of the hangover tree, also known as “Ke tuu tu”, a tree with neutral properties, non-toxic, has the effect of clearing dampness and heat, detoxifying alcohol, and has a sweet taste. The hangover tree is 7-10m tall, the fruit is spherical, gray-brown, when ripe the branches (peduncles) bear large, juicy, pink, sweet, edible fruit, with round, flat, shiny brown seeds.
In 2008, it was estimated that approximately 1 million people die each year from hepatitis B (HBV), which means that 115 people die every hour from HBV turning into primary hepatocellular carcinoma (HCC) or liver failure due to HBV. The proportion of Asians, sub-Saharan Africans with HBV in their serum is high. A 1981 study of 22,707 Taiwanese people infected with HBV found that 90% developed primary liver cancer after 8-9 years. In the United States, Vietnamese Americans have a 9 times higher infection rate than non-Hispanic Americans. There is ample evidence that the human hepatitis B virus, derived from the Woodchucks hepatitis virus (WHV), causes primary liver cancer and is transmitted to humans during the birth cycle.
Currently, Interferon alpha 2b and 2a and Ribavirin inhibit HBV, but also cause many side effects such as: muscle pain, joint pain, loss of taste, loss of appetite, inhibition of saliva secretion, dry mouth, weight loss, fatigue, dry skin, rash, hair loss... Moreover, as introduced above, HBV often invades and hides in the nucleus of liver cells. When exposed to drugs, they seem to know how to "hide", when the concentration of drugs in the plasma decreases, they reappear. Long-term treatment with modern drugs causes more side effects. Therefore, people are trying to find drugs to treat liver diseases of natural origin. The active ingredients in medicinal plants are less toxic, because they have existed for many years in plant cells. When entering liver cells, they are more adaptable, so they are less toxic, compared to modern drugs, which have never existed in living cells.
Alcohol and beer have the main ingredient of ethanol, when entering the body with the help of ADH enzyme, degraded in the liver into acetic acid, this substance is converted by ALDH enzyme into toxic acethaldehyde , causing damage to the DNA of liver cells, forming scars in the liver, leading to cirrhosis and then cancer. Alcohol also causes the liver to become fatty quickly, reducing liver function. Too high blood alcohol concentration also directly causes "alcoholic hepatitis", leading to chronic hepatitis, cirrhosis, loss of liver function, making toxins in the liver unable to be eliminated. In addition, due to diuretic, alcohol causes dehydration of the skin, dry skin, dark skin, hair is easy to dry, and fall out quickly. Alcohol also affects the neurotransmitter acetylcholine, thereby causing depression. Alcohol also increases blood pressure, causes death of heart and kidney muscle cells, reduces the contractility of the heart, reduces the filtering ability of the kidneys, damages the kidneys...
Professor Page and his colleagues at the University of Hudderfield discovered a substance called “Etan-beta-Sultam”, which when injected into mice that had been given alcohol, reduced brain cell loss and inflammation. The brain protects itself with glial cells, which increase their secretion when alcohol is present. When encountering the substance that Professor Page named Etan-beta-Sultam, it was found that there was a reduction in the level of damage to the glial cells secreted by the brain, to protect itself from the harmful effects of alcohol. Based on the above principle, scientists have tried to find natural substances that have the effect of detoxifying alcohol, reducing the toxicity of alcohol in liver cells.
Research projects in the past 20 years in Japan and Korea have proven that the active ingredient Dihydromyricetin, also known as Ampelopsin from the Hovenia dulcis plant, has the effect of detoxifying alcohol and protecting the liver, preventing cirrhosis, by reducing the level of alcohol circulating in the blood, due to the Dihydromyricetin in the Hovenia dulcis plant extract, which has the effect of reducing the activity of the two enzymes ADH and ALDH, preventing the conversion of alcohol into acetic acid and acethaldehyde, increasing the process of eliminating alcohol from the body.
The hangover tree is an imported plant, currently growing in Cao Bang and Lang Son. The medicinal herb “Chi cu tu” is the fruit and the fruit-bearing branches of the hangover tree, also known as “Ke tuu tu”, a tree with neutral properties, non-toxic, has the effect of clearing dampness and heat, detoxifying alcohol, and has a sweet taste. The hangover tree is 7-10m tall, the fruit is spherical, gray-brown, when ripe the branches (peduncles) bear large, juicy, pink, sweet, edible fruit, with round, flat, shiny brown seeds.
The seeds of the hangover tree contain the alkaloid perlorin, the leaves and fruits contain triterpene saponins (hovenidulcinosid A1 and A2, B1 and B2) which have the effect of inhibiting histamine release, anti-allergy and protecting the liver. The flavonoid compound Dihydromyricetin (Ampelopsin) and 3 other flavonoid derivatives have the effect of both protecting the liver and reducing the level of alcohol circulating in the blood (alcohol detoxification). When rabbits were given the fruit extract of the hangover tree at a dose of 487.8 mg/kg body weight, and at the same time given alcohol at a dose of 3 g/kg, after 2 hours in the group of rabbits that did not drink the hangover tree extract, the alcohol concentration was 29nM, while in the group of rabbits that drank the hangover tree extract, this concentration was only 5nM. The active ingredient Dihydromyricetin is said to have an anti-alcohol-effect. In addition, the methanol extract of the fruit of the hangover plant also has a liver-protective effect (due to dihydromyricetin) in the Tetrachlorocarbon-induced liver toxicity model at doses of 100, 350 and 600 mg/kg. The saponins hovenidulciosid A1 and A2 have the effect of inhibiting histamine in macrophages, through an anti-allergic mechanism with IC50 values of 29.2 and 53.2 nM, thereby demonstrating immunoregulatory and anti-inflammatory effects. The hangover plant is not toxic. People gave mice the highest possible dose (22 g/kg) without any deaths, proving that the hangover plant is not toxic.
According to traditional medicine, the hangover cure plant has the effect of detoxifying, clearing fire, dispelling yang, nourishing yin, not punishing, but when going up it cools the fire above, when going down it cools the fire below, cools the blood, regulates taste, opens depression, removes annoyance, cools the depression heat of the heart fire, treats the madness caused by yang poison, removes alcohol poison, treats fullness, treats all kinds of damp heat, and all kinds of poisons caused by the weather.
Hoganbo-HD1 product from Korea is the result of 10 years of continuous research by Dr. Na Cheonsu. HD1 is extracted from the fruit of the hangover tree and has the effect of protecting the liver. Hoganbo HD1 has been granted many domestic and international patents such as: Korea # 0403721; USA # 622358; Japan # 3178806; China # ZL02827195.5; Canada # 2235565 and 13 inventions related to its effects on humans. Hoganbo-HD1 is the only liver function enhancing product that received an award from former Korean President Kim Daejung in 2001. Hoganbo-HD1 has also been granted registration number KFDA # 14359537408 in 2008 by the Korean Food and Drug Administration.
Hoganbo-HD1 enhances liver function, helps the liver to decompose and eliminate toxins, promotes the regeneration of new liver cells, and restores damaged liver cells.
Hoganbo HD1 is useful for: Children with poor appetite, physical weakness; People who often stay up late, have stressful and tiring jobs; People with liver diseases such as high liver enzymes, fatty liver, hepatitis, impaired liver function; People addicted to cigarettes, drinking a lot of beer and alcohol; People who often have to take Western medicine, people who need to cool down and detoxify; People with jaundice, body fatigue, rash, bad breath...
Currently, Interferon alpha 2b and 2a and Ribavirin inhibit HBV, but also cause many side effects such as: muscle pain, joint pain, loss of taste, loss of appetite, inhibition of saliva secretion, dry mouth, weight loss, fatigue, dry skin, rash, hair loss... Moreover, as introduced above, HBV often invades and hides in the nucleus of liver cells. When exposed to drugs, they seem to know how to "hide", when the concentration of drugs in the plasma decreases, they reappear. Long-term treatment with modern drugs causes more side effects. Therefore, people are trying to find drugs to treat liver diseases of natural origin. The active ingredients in medicinal plants are less toxic, because they have existed for many years in plant cells. When entering liver cells, they are more adaptable, so they are less toxic, compared to modern drugs, which have never existed in living cells.
Alcohol and beer have the main ingredient of ethanol, when entering the body with the help of ADH enzyme, degraded in the liver into acetic acid, this substance is converted by ALDH enzyme into toxic acethaldehyde , causing damage to the DNA of liver cells, forming scars in the liver, leading to cirrhosis and then cancer. Alcohol also causes the liver to become fatty quickly, reducing liver function. Too high blood alcohol concentration also directly causes "alcoholic hepatitis", leading to chronic hepatitis, cirrhosis, loss of liver function, making toxins in the liver unable to be eliminated. In addition, due to diuretic, alcohol causes dehydration of the skin, dry skin, dark skin, hair is easy to dry, and fall out quickly. Alcohol also affects the neurotransmitter acetylcholine, thereby causing depression. Alcohol also increases blood pressure, causes death of heart and kidney muscle cells, reduces the contractility of the heart, reduces the filtering ability of the kidneys, damages the kidneys...
Professor Page and his colleagues at the University of Hudderfield discovered a substance called “Etan-beta-Sultam”, which when injected into mice that had been given alcohol, reduced brain cell loss and inflammation. The brain protects itself with glial cells, which increase their secretion when alcohol is present. When encountering the substance that Professor Page named Etan-beta-Sultam, it was found that there was a reduction in the level of damage to the glial cells secreted by the brain, to protect itself from the harmful effects of alcohol. Based on the above principle, scientists have tried to find natural substances that have the effect of detoxifying alcohol, reducing the toxicity of alcohol in liver cells.
Research projects in the past 20 years in Japan and Korea have proven that the active ingredient Dihydromyricetin, also known as Ampelopsin from the Hovenia dulcis plant, has the effect of detoxifying alcohol and protecting the liver, preventing cirrhosis, by reducing the level of alcohol circulating in the blood, due to the Dihydromyricetin in the Hovenia dulcis plant extract, which has the effect of reducing the activity of the two enzymes ADH and ALDH, preventing the conversion of alcohol into acetic acid and acethaldehyde, increasing the process of eliminating alcohol from the body.
The hangover tree is an imported plant, currently growing in Cao Bang and Lang Son. The medicinal herb “Chi cu tu” is the fruit and the fruit-bearing branches of the hangover tree, also known as “Ke tuu tu”, a tree with neutral properties, non-toxic, has the effect of clearing dampness and heat, detoxifying alcohol, and has a sweet taste. The hangover tree is 7-10m tall, the fruit is spherical, gray-brown, when ripe the branches (peduncles) bear large, juicy, pink, sweet, edible fruit, with round, flat, shiny brown seeds.
The seeds of the hangover tree contain the alkaloid perlorin, the leaves and fruits contain triterpene saponins (hovenidulcinosid A1 and A2, B1 and B2) which have the effect of inhibiting histamine release, anti-allergy and protecting the liver. The flavonoid compound Dihydromyricetin (Ampelopsin) and 3 other flavonoid derivatives have the effect of both protecting the liver and reducing the level of alcohol circulating in the blood (alcohol detoxification). When rabbits were given the fruit extract of the hangover tree at a dose of 487.8 mg/kg body weight, and at the same time given alcohol at a dose of 3 g/kg, after 2 hours in the group of rabbits that did not drink the hangover tree extract, the alcohol concentration was 29nM, while in the group of rabbits that drank the hangover tree extract, this concentration was only 5nM. The active ingredient Dihydromyricetin is said to have an anti-alcohol-effect. In addition, the methanol extract of the fruit of the hangover plant also has a liver-protective effect (due to dihydromyricetin) in the Tetrachlorocarbon-induced liver toxicity model at doses of 100, 350 and 600 mg/kg. The saponins hovenidulciosid A1 and A2 have the effect of inhibiting histamine in macrophages, through an anti-allergic mechanism with IC50 values of 29.2 and 53.2 nM, thereby demonstrating immunoregulatory and anti-inflammatory effects. The hangover plant is not toxic. People gave mice the highest possible dose (22 g/kg) without any deaths, proving that the hangover plant is not toxic.
According to traditional medicine, the hangover cure plant has the effect of detoxifying, clearing fire, dispelling yang, nourishing yin, not punishing, but when going up it cools the fire above, when going down it cools the fire below, cools the blood, regulates taste, opens depression, removes annoyance, cools the depression heat of the heart fire, treats the madness caused by yang poison, removes alcohol poison, treats fullness, treats all kinds of damp heat, and all kinds of poisons caused by the weather.
Hoganbo-HD1 product from Korea is the result of 10 years of continuous research by Dr. Na Cheonsu. HD1 is extracted from the fruit of the hangover tree and has the effect of protecting the liver. Hoganbo HD1 has been granted many domestic and international patents such as: Korea # 0403721; USA # 622358; Japan # 3178806; China # ZL02827195.5; Canada # 2235565 and 13 inventions related to its effects on humans. Hoganbo-HD1 is the only liver function enhancing product that received an award from former Korean President Kim Daejung in 2001. Hoganbo-HD1 has also been granted registration number KFDA # 14359537408 in 2008 by the Korean Food and Drug Administration.
Hoganbo-HD1 enhances liver function, helps the liver to decompose and eliminate toxins, promotes the regeneration of new liver cells, and restores damaged liver cells.
Hoganbo HD1 is useful for: Children with poor appetite, physical weakness; People who often stay up late, have stressful and tiring jobs; People with liver diseases such as high liver enzymes, fatty liver, hepatitis, impaired liver function; People addicted to cigarettes, drinking a lot of beer and alcohol; People who often have to take Western medicine, people who need to cool down and detoxify; People with jaundice, body fatigue, rash, bad breath...
Associate Professor, PhD, Senior Researcher Nguyen Thuong Dong - Center for Continuing Education in Pharmacy
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